Comparison of Mounjaro, Wegovy and MySimba
WHICH WEIGHT LOSS MEDICATION IS RIGHT FOR ME?
Please do have a look at the table, which tells you the main differences among the different medications available for weight loss in the UK.
If you are interested in having a prescription but you need more information, please do check out the rest of this section of our website, or contact us if you have any questions.
| Medication | Mounjaro | Wegovy | Mysimba |
|---|---|---|---|
| Type of medication | Weekly injection | Weekly injection | Daily tablets |
| Active ingredient(s) | Tirzepatide | Semaglutide | Bupropion Naltrexone |
| Expected weight loss | 22% | 14% | 5% |
| Mechanism of action | Increasing GLP1 and GIP, slows down food transit time, direct message to the brain to reduce food intake | Increasing GLP1 and GIP, slows down food transit time, direct message to the brain to reduce food intake | Reduces food addiction and cravings. |
| Possible side effects | Heartburn, nausea, vomiting, bloating, heartburn, constipation, diarrhoea, dizziness, low blood pressure, hair loss, fatigue, gall stones, low blood sugar, pancreatitis | Heartburn, nausea, vomiting, bloating, heartburn, constipation, diarrhoea, dizziness, low blood pressure, hair loss, fatigue, gall stones, low blood sugar, pancreatitis, worsening of diabetic retinopathy | Fits (rarely but importantly), worsening depression, nausea/vomiting, constipation, headache, anxiety, dizziness, difficulty sleeping, dry mouth, difficulty concentrating, fatigue, tinnitus, fast heart rate, hot flush, increased blood pressure, abdominal pain, rash, itching, excessive sweating, hair loss, irritability |
| Cost | £185-£220 per month | £165-£290 per month | £115 per month |
| Who can have it | BMI >30 or >27 with at least one weight related health problem | BMI >30 or >27 with at least one weight related health problem | BMI >30 or >27 with at least one weight related health problem |
| Who shouldn’t take it | History of pancreatitis, gall stones, thyroid cancer | History of pancreatitis, gall stones, thyroid cancer, diabetic retinopathy | History of fits and depressed mood, currently undergoing treatment for substance misuse or taking strong prescription painkillers |
| Storage | In a refrigerator until open, then below 30 degrees celsius | In a refrigerator until open, then below 30 degrees celsius | Below 30 degrees celsius |
| Suitable during pregnancy/breast feeding | No | No | No |